Environmental impact assessment for veterinary medicinal products (VMP) according
CVMP/VICH/790/03-FINAL

Phase II: Tier A

• Physico-chemical Properties

   - UV/VIS absorption spectra
   - Melting point / Melting range
   - Water solubility
   - Partition Coefficient log Kow
   - Dissociation constant in water
   - Vapour pressure (calculation)

• Terrestrial Ecotoxicology

   - Nitrogen transformation
   - Terrestrial plants growth
   - Earthworm subacute / reproduction

• Environmental Fate

   - Biodegradation (soil or aquatic)
   - Adsorption / Desorption in soil Kd / Koc
   - Photolysis (optional)
   - Hydrolysis (optional)

• Aquatic Ecotoxicology

   - Algae growth inhibition
   - Dapphnia immobilisation
   - Fish acute toxicity
     (Additional salt water test systems for products used for aquaculture)

Phase II: Tier B

• Depending on the results of the studies from Tier A, additional studies are necessary:

   - Environmental Fate
   - Terrestrial Ecotoxicology
   - Aquatic Ecotoxicology